TMG Supplement

Looking for a simple way to support your health and wellbeing on the day-to-day? Our TMG Supplement delivers a strong source of pure Betaine in one convenient, high-strength, vegan-friendly capsule.

Key Benefits

• May support performance and recovery
• Linked to longevity and healthy ageing
• Contributes to normal homocysteine metabolism

Product Overview

Trimethylglycine (TMG) is a derivative of the amino acid glycine. It’s sometimes referred to as betaine, and it’s best known for being a methyl donor, a nutrient that gives its methyl groups to other molecules, allowing your body to perform important biochemical reactions.

Diet can give you small amounts of TMG, but supplementing is the easiest and most consistent way to boost your intake. Each TMG capsule contains 686mg of pure betaine anhydrous, with no fillers or unnecessary extras.

Adding TMG to your wellness routine is quick, easy, and effective, whether your goal is longevity focused, preserving heart health, or simply looking after your body every day.

• Vegan-friendly, suitable for all diets
• 686mg of pure betaine (TMG) per capsule
• 60 servings
• Quick and easy to take
• Backed by third-party testing

Read our Certificate of Analysis (CoA)

Dosage 

• Take 1 capsule per day with water, ideally with food.
• Stick to the recommended dose, more is not always better.
• Not suitable for children, or for women who are pregnant or breastfeeding.

Ingredients

Betaine anhydrous, Glazing Agent (Capsule (Hydroxypropyl Methylcellulose))1.1VcapsPlus®

Nutritional Information

Certainty of Purity

We understand that when it comes to supplements, quality matters. That’s why every batch of our TMG Supplement is third-party tested for safety and purity.

Our TMG is derived from betaine anhydrous, a naturally occurring compound found in plants like beetroot. It’s a reliable source of trimethylglycine, working as a methyl donor, similar to folate and creatine, and as an osmoregulator, supporting balance at the cellular level.

With Naturecan, you get:

• High-quality ingredients made in Europe
• Full transparency at every step
• Science-backed formulas
• A sustainable promise to do better for you and the planet

Are TMG Supplements Right for You?

TMG could be a great fit if you’re:

• Looking to support heart health
• Interested in promoting longevity and healthy ageing
• Keen to keep homocysteine levels balanced
• Building a wellness routine that supports your body at a cellular level

Why you should combine TMG & NMN

Combining Naturecan’s TMG (Trimethylglycine) with NMN (Nicotinamide Mononucleotide) creates a powerful synergy for cellular health and longevity support. 

NMN helps boost NAD⁺ levels, which play a key role in energy production and healthy aging, while TMG supports methylation pathways that can become depleted during NAD⁺ metabolism. 

By pairing TMG with NMN, you help maintain optimal methyl balance, support cardiovascular health, and promote more efficient cellular energy, making the benefits of NMN supplementation more complete and sustainable [1,2]

Get more from your TMG. Pair it with Naturecan’s NMN and upgrade your longevity stack today.

Ingredients Explained

What is betaine?

Betaine is simply another name for trimethylglycine. It’s found naturally in foods like beetroot and spinach, and is one of the purest, strongest forms of TMG.

As a methyl donor, it helps with important metabolic processes, including homocysteine regulation. It also acts as an osmoregulator, which means it helps cells manage their water balance.

By supplementing with betaine, you get a consistent and reliable way to support your body’s natural processes, without relying solely on diet.

Lead By Experts & Trusted Professionals

Key Studies

• Cardiovascular and metabolic health: Research shows that betaine supports healthy methylation and cardiovascular function. [1]
• Homocysteine regulation: A clinical trial found TMG lowered plasma homocysteine levels in healthy men and women both immediately, and over a prolonged period of time. [2]
• Longevity link: Emerging evidence suggests methyl donors, including betaine, may play a role in slowing age-related decline. [3]

References

1. Friso S. One-carbon metabolism and epigenetics. Molecular Aspects of Medicine. 2017;54:28–36. PMID: 27876555
   
2. Arumugam A et al. Beneficial effects of betaine: comprehensive review. Nutrients. 2021; PMID: 34067313.
   
3. Wang, Z., et al. (2021). Beneficial Effects of Betaine: A Comprehensive Review. Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC8224793/
   
4. Olthof, M.R., et al. (2003). Immediate and long-term reduction of plasma homocysteine in healthy men and women by betaine supplementation. Available at: https://pubmed.ncbi.nlm.nih.gov/14652361/
5. Zhang, H., et al. (2024). Methyl donors and their anti-ageing potential. Ageing Research Reviews. Available at: https://www.sciencedirect.com/science/article/abs/pii/S1568163724004525